Hypertension doubles the cardiovascular risk, high blood cholesterol triples the risk, while the combined effect of these two factors is a six times greater risk of cardiovascular diseases. Thus, a combination treatment reducing blood pressure and improving the lipid profile is a logical approach.
The best currently available evidence from clinical trials and guidelines supports the routine use of this approach and recommends the routine use of statins in the majority of hypertensive patients.
Some data indicate that a specific combination of statins and antihypertensive drugs can generate interaction beneficial to cardiovascular outcomes. It seems that this therapeutic combination should become a cornerstone of the standard treatment of hypertension.
Even if there was no synergy, the Anglo-Scandinavian Cardiac Outcomes Trial ASCOT has clearly demonstrated significant positive effects associated with administration of amlodipine and perindopril with atorvastatin at all levels of cardiovascular outcomes. Key words:.